Platform Technology for
       Minimally Invasive Medical Devices

Path Scientific, LLC ("PSL" or "Company") is a small medical device company located just outside of Boston, Massachusetts. PSL was founded by Terry Herndon in 2004 after retiring from a long and distinguished career at MIT's Lincoln Laboratories.

Shortly before the Company's inception Herndon became focused on drug delivery methodology. In this regard, Herndon began developing a painless drilling technology for skin and nail. The technology relies on the difference in electrical impedance between the outermost layer of skin or nail and bodily fluids to signal precise forward and rapid reverse actions to painlessly create openings in stratum corneum or nail plate. An added feature is an abrasion capability which can painlessly create multiple microconduits through skin, thus allowing the transdermal delivery of even large molecule drugs. Herndon's technology, which has been assigned to PSL, is secured by several patents with priority dates ranging from 2003-2014.

One of the micro-motors which advances and retracts the cutting member additionally has stepping capability that provides the ability to drill to extremely precise depths in bone or nail. An added feature relies on current drawn to signal the approach of dorsal boundaries for applications, such as orthopedic drilling, where penetration of the dorsal wall is undesirable.

Once the base technology had been developed, various other applications became revealed. Description summaries of known and assumed applications appear below:

1. Integrated Blood Sampling and Analyte Measurement

  1. A recent patent-pending technology developed by PSL enables painless, one-step blood collection and glucose measurement. The technology uses surface tension between the fluid and the cutter to collect the fluid.
  2. The technology has great potential in the growing realm of point of care testing (PoTC).

2. Transdermal Drug Delivery

  1. Painless removal of the stratum corneum by sensing thru-skin electrical impedance and rapidly removing the cutter before it reaches the nerve bed, thus permitting needle-free delivery of large molecule drugs.
  2. Prompt treatment of neonates by allowing rapid delivery of lidocaine (e.g., 2 minute vs. 30 minute action) via the painless removal of stratum corneum for the numbing of hypodermic needle sites.
  3. Faster, more extensive, drug delivery through simultaneously opened, sensation-free, multiple microconduits in the stratum corneum.

3. Podiatric Treatment

  1. Effective topical treatment of nail fungus, onychomycosis, via microconduits formed painlessly in nails allowing anti-fungal agents direct access to target. (A small clinical trial conducted at a major Boston teaching hospital has indicated the efficacy of a topical fungicide in this application.)
  2. Rapid relief of "Black Toe" by drilling painlessly through nail to blood bolus site to release pressure. (For use by podiatrists, EMTs', military, runners, athletes, etc., FDA 510(K) approval has been obtained for this use.)

4. Orthopedic Surgery

  1. Precise depth control while drilling bone to minimize "blind hole" volume and prevent dorsal side penetration for orthopedic and spine surgery.
  2. In vivo bone contouring by means of a cutter "dithering" capability to achieve planarization of bone surface, creation of controlled depth slots in bone, etc.

5. Neurosurgery

  1. Accurate and safe pedicle screw placement.
  2. Precision depth and plunge depth measurement and control for drilling through and/or into bone.

6. Neurological Monitoring

  1. Reduction of thru-skin electrical impedance, thus increasing the reliability and accuracy of EKG electrical measurements, and other biosensors.

7. Oncological Testing

  1. Efficient facilitation of bone marrow aspiration.

8. Cosmetic Applications

  1. Rapid hair transplant site generation to precise site depth.
  2. Needle-free Botox infusions for smoothing skin wrinkles.
  3. Painless engraving of nail surfaces in cutter "dithering" mode.

PSL is a non-practicing entity and seeks to commercialize its technology through license or assignment.